Solid Basal Cell Epithelioma Possibly Originates From the Outer Root Sheath of the Hair Follicle

    August 1993 in “ PubMed ”
    Masahito Asada, Frank-Matthias Schaart, Hiram Larangeira de Almeida, Bernhard Korge, Ichiro Kurokawa, Yoshimasa Asada, Orfanos Ce
    Studysummary This study found that solid basal cell epitheliomas and the outer root sheath of human hair follicles display nearly identical cytokeratin profiles, suggesting a potential origin connection.
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    The study investigated the presence and distribution of cytokeratins (CKs) in 20 solid basal cell epitheliomas (BCEs) and compared them with normal epidermis and the outer root sheath (ORS) of hair follicles. The findings showed that BCE and ORS shared similar CK profiles, particularly CKs 5, 6, 14, 16, and 17, which were distinct from the CK pattern of normal epidermis. This similarity suggested that the lower ORS might serve as a cellular pool for the generation of BCE. The study highlighted the potential origin of BCE from the ORS of hair follicles, supported by immunohistochemical and biochemical analyses.
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