Solid Basal Cell Epithelioma Possibly Originates From the Outer Root Sheath of the Hair Follicle

August 1993 in “ PubMed ”

Masahito Asada, Frank-Matthias Schaart, Hiram Larangeira de Almeida, Bernhard Korge, Ichiro Kurokawa, Yoshimasa Asada, Orfanos Ce

basal cell epithelioma outer root sheath hair follicle cytokeratin CK5 CK6 CK14 CK16 CK17 monoclonal antibodies gel electrophoresis

TLDR Basal cell epithelioma likely starts from the hair follicle's outer root sheath.

The study investigated the presence and distribution of cytokeratins (CKs) in 20 solid basal cell epitheliomas (BCEs) and compared them with normal epidermis and the outer root sheath (ORS) of hair follicles. The findings showed that BCE and ORS shared similar CK profiles, particularly CKs 5, 6, 14, 16, and 17, which were distinct from the CK pattern of normal epidermis. This similarity suggested that the lower ORS might serve as a cellular pool for the generation of BCE. The study highlighted the potential origin of BCE from the ORS of hair follicles, supported by immunohistochemical and biochemical analyses.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 2 years ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community When you're balding is it an absolute traumatic period of your life or do some people not care as much?

in Chat 88 upvotes 1 year ago

Balding can be traumatic for many, affecting self-esteem and social interactions, while others accept it more easily. Treatments mentioned include finasteride, minoxidil, and RU58841.

community The case of a 78 year old man who accidentally regrew his hair (published in the British Medical Journal)

in Chat 216 upvotes 2 months ago

A 78-year-old man regrew hair after suffering burns, suggesting that injury-induced healing processes might trigger hair growth. Microneedling and other treatments like minoxidil and finasteride are discussed as potential methods to stimulate similar regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Doctor says i shouldn't take fin because its "hormonal"

in Finasteride/Dutasteride 105 upvotes 1 year ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

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research Study on the Distribution of Hair Keratin in Normal Hair Follicles by Immunohistochemical Staining

January 2000 in “Acta Academiae Medicine Militaris Tertiae”

Different keratins in hair follicles can help identify hair tumor origins.

research Solid Basal Cell Epithelioma Possibly Originates From the Outer Root Sheath of the Hair Follicle

61 citations , August 1993 in “PubMed”

Basal cell epithelioma likely starts from the hair follicle's outer root sheath.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research Immunohistochemical Staining Characteristics of Epidermal Appendages: Hair Follicles and Eccrine Sweat Glands to Anti-Epidermal Keratin Antisera

6 citations , November 1984 in “Acta Dermato Venereologica”

Hair follicles and sweat glands show different keratin staining patterns.