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GlossaryKeratin 5 (CK5)

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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research Use of Ultra-Fast One-Step CK5 IHC for Identifying BCC and SCC During Mohs Surgery

1 citations , April 2017 in “Journal of Investigative Dermatology”

A new one-step test can quickly identify skin cancer during surgery.

research Solid Basal Cell Epithelioma Possibly Originates From the Outer Root Sheath of the Hair Follicle

61 citations , August 1993 in “PubMed”

Basal cell epithelioma likely starts from the hair follicle's outer root sheath.

research Cytokeratin Expression of Apocrine and Eccrine Poromas with Special Reference to Its Expression in Cuticular Cells

37 citations , August 2000 in “Journal of Cutaneous Pathology”

Poromas are related to sweat duct cells, and CK patterns help distinguish apocrine poromas from other neoplasms.

research Immunohistochemical Demonstration of Keratins in the Epidermal Layers of the Malayan Pangolin, with Remarks on the Evolution of the Integumental Scale Armour

28 citations , September 2013 in “European Journal of Histochemistry”

Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.

research Keratinic Amyloid Deposition in Canine Hair Follicle Tumors

1 citations , October 2022 in “Veterinary pathology”

Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.

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A 24-year-old experienced significant hair regrowth over 8 months using oral finasteride, oral and topical minoxidil, dutasteride, microneedling, and ketoconazole shampoo. They are satisfied with the results and may consider a hair transplant after one year.