Keratinic Amyloid Deposition in Canine Hair Follicle Tumors

    October 2022 in “ Veterinary pathology ”
    Kyoko Kobayashi, Susumu Iwaide, Hiroki Sakai, Fuyuki Kametani, Tomoaki Murakami
    Image of study
    TLDR Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.
    This study examined keratinic amyloid deposition in canine hair follicle tumors, a previously unreported condition in animals. Out of 266 samples, 16 showed amyloid deposits, mainly in the tumor stroma and around hair follicles. Cytokeratin 5 (CK5) was identified as a precursor protein, with C-terminal truncation observed in the deposits. Shiba dogs had a higher incidence of amyloid deposition, and CK5 amino acid polymorphisms were found in these dogs. The study found that both canine and human CK5 have highly amyloidogenic properties, providing new insights into the etiology of cutaneous amyloidosis.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 141 results

      community Keratin fibers vs. Gossypium Herbaceum Hair fibers

      in Product  1 upvotes 1 year ago
      The conversation is about comparing keratin hair fibers to Gossypium Herbaceum hair fibers for diffuse hair loss. The user prefers keratin fibers for their durability and is seeking a bulk purchase option.

      community Keratin microspheres - breakthrough

      in Research/Science  15 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Discussion: Keratin Microsphere Results

      in Treatment  34 upvotes 1 year ago
      Keratin microspheres may offer additional mechanisms to combat hair loss compared to minoxidil. The process to create these microspheres is relatively simple and can be done at home with basic equipment.

      community Let's talk keratin products and hair loss

      in Styling  2 upvotes 2 weeks ago
      OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

    Related Research

    2 / 2 results