Keratinic Amyloid Deposition in Canine Hair Follicle Tumors

    October 2022 in “ Veterinary pathology ”
    Kyoko Kobayashi, Susumu Iwaide, Hiroki Sakai, Fuyuki Kametani, Tomoaki Murakami
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    TLDR Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.
    This study examined keratinic amyloid deposition in canine hair follicle tumors, a previously unreported condition in animals. Out of 266 samples, 16 showed amyloid deposits, mainly in the tumor stroma and around hair follicles. Cytokeratin 5 (CK5) was identified as a precursor protein, with C-terminal truncation observed in the deposits. Shiba dogs had a higher incidence of amyloid deposition, and CK5 amino acid polymorphisms were found in these dogs. The study found that both canine and human CK5 have highly amyloidogenic properties, providing new insights into the etiology of cutaneous amyloidosis.
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