Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit

August 2017 in “ Journal of comparative pathology ”

Mun Keong Kok, James Chambers, Nanako Ushio, A. Watamori, Yoshiyuki Miwa, Hiroyuki Nakayama, Kazuyuki Uchida

trichoblastoma histopathological immunohistochemical CK14 CK17 papillary mesenchymal bodies trichogenesis basal-type cells hair follicle

Studysummary This study suggests that uncontrolled embryonic trichogenesis may play a role in the development of trichoblastoma in rabbits. Our plain-language summary of this paper — not a Tressless recommendation.

The study characterized the histopathological and immunohistochemical features of trichoblastoma in 27 rabbits, examining 30 tumors. Trichoblastomas were most commonly found on the neck, head, flank, and hindlimb. Histologically, the tumors were categorized into ribbon, trabecular, and mixed types, with 80% showing prominent fibroblastic aggregation (papillary mesenchymal bodies). Immunohistochemically, peripheral palisading basal-type cells were positive for CK14, while inner cells were positive for CK17, differing from normal rabbit epidermis and hair follicle profiles. The study suggested that uncontrolled embryonic trichogenesis might be involved in trichoblastoma development in rabbits, and highlighted the importance of papillary mesenchymal bodies as a histological feature.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research The Clinicopathological Spectrum of Trichoepitheliomas: A Retrospective Descriptive Study

6 citations , July 2015 in “International Journal of Dermatology”

This study observed that multiple familial trichoepitheliomas commonly presented with a cribriform histopathological tumor pattern, differentiating them from solitary trichoepitheliomas.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research The Human Keratins: Biology And Pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.