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GlossaryImmunostaining (Immunohistochemistry)

technique using antibodies to detect specific proteins in tissues

Immunofluorescence (IF) is a laboratory technique used to visualize the presence and location of specific proteins or antigens in cells or tissue sections by using antibodies that are chemically linked to a fluorescent dye. When these antibodies bind to their target, the fluorescent dye can be seen under a microscope with the appropriate light, allowing researchers to study the distribution and abundance of the proteins of interest.

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research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

100 citations , September 1999 in “British Journal of Dermatology”

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

research Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study

86 citations , August 2000 in “Pigment cell research”

Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.

research Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

73 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Markers help differentiate between apocrine and eccrine sweat glands to identify sweat gland tumors.

Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia

research Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia

36 citations , June 2014 in “PLOS ONE”

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

research Immunohistochemical Detection of Cytochrome P450 Isoenzymes in Cultured Human Epidermal Cells

19 citations , December 1990 in “Journal of Histochemistry & Cytochemistry”

Foreskin keratinocytes and SVK14 cells express certain cytochrome P450 enzymes, unlike hair follicle keratinocytes.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 414 upvotes 5 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 10 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Another clueless guy fearmongering and spreading misinformation

in Chat 251 upvotes 1 year ago

The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.