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GlossaryHistopathological

microscopic examination of tissue to study disease manifestations

Histopathological refers to the microscopic examination of tissue in order to study the manifestations of disease. This process, also known as histopathology, involves analyzing tissue samples under a microscope to identify abnormalities, such as those seen in conditions like alopecia, where hair follicles might show specific patterns of inflammation or damage.

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research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations, August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

research Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

16 citations, May 2013 in “Australasian Journal of Dermatology”

Hair loss in Cronkhite-Canada syndrome is reversible by treating the gut issues and doesn't need steroid treatment for the hair itself.

research Primary Scalp Alopecia: New Histopathological Tools, New Concepts, and a Practical Guide to Diagnosis

14 citations, September 2016 in “Journal of Cutaneous Pathology”

The document concludes that new methods improve the accuracy of diagnosing scalp alopecia and challenges the old way of classifying it.

Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

research Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

10 citations, February 2010 in “Acta Histochemica Et Cytochemica”

c-kit affects hair growth and color in alopecia areata and androgenetic alopecia.

research Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit

9 citations, August 2017 in “Journal of comparative pathology”

Trichoblastomas in rabbits are linked to uncontrolled embryonic hair growth and have distinct histological features.

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community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 week ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.