Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

    February 2010 in “ Acta Histochemica Et Cytochemica ”
    Md. Ashrafuzzaman, Tomoko Yamamoto, Noriyuki Shibata, Takeshi Thomas Hirayama, Makio Kobayashi
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    TLDR c-kit affects hair growth and color in alopecia areata and androgenetic alopecia.
    This study investigated the potential involvement of the stem cell factor receptor c-kit in alopecia areata (AAR) and androgenetic alopecia (AGA). The study analyzed scalp biopsy specimens from 14 AAR patients, 18 AGA patients, and 6 control subjects with other diseases. The study found that c-kit is expressed in the cells responsible for hair growth and color in the hair follicle, and that the SCF/c-kit signaling pathway may be involved in the pathological processes of AAR and AGA. The study used histopathological, immunohistochemical, and semiquantitative analyses to investigate c-kit expression.
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