Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

    January 2010 in “ Acta Histochemica Et Cytochemica ”
    Md. Ashrafuzzaman, Tomoko Yamamoto, Noriyuki Shibata, Takeshi Thomas Hirayama, Makio Kobayashi
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    TLDR c-kit affects hair growth and color in alopecia areata and androgenetic alopecia.
    This study investigated the potential involvement of the stem cell factor receptor c-kit in alopecia areata (AAR) and androgenetic alopecia (AGA). The study analyzed scalp biopsy specimens from 14 AAR patients, 18 AGA patients, and 6 control subjects with other diseases. The study found that c-kit is expressed in the cells responsible for hair growth and color in the hair follicle, and that the SCF/c-kit signaling pathway may be involved in the pathological processes of AAR and AGA. The study used histopathological, immunohistochemical, and semiquantitative analyses to investigate c-kit expression.
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      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.
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      community What hair loss pattern is this?

      in General  157 upvotes 2 weeks ago
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