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Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles

research Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles

39 citations , January 2008 in “Journal of Endocrinology”

This study found that in androgenetic alopecia, reduced stem cell factor production by dermal papilla cells may lead to decreased pigmentation in hair follicles.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

research Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency

15 citations , January 2010 in “Experimental Dermatology”

This study found that maternal iron-restricted diets increased alopecia incidence in IL-10-deficient mouse pups with mast cells, implicating mast cells as potential effectors in this process.

Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

research Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

10 citations , January 2010 in “Acta Histochemica Et Cytochemica”

This study found that patients with alopecia areata and androgenetic alopecia showed increased c-kit expression and decreased Ki-67 expression in hair follicle cells compared to controls, suggesting a possible feedback mechanism involving stem cell factor signaling.

research Repigmentation of leukoderma in a piebald patient associated with a novel c-KIT gene mutation, G592E, of the tyrosine kinase domain

6 citations , November 2011 in “Journal of Dermatological Science”

A new gene mutation may allow some piebaldism patients to regain skin color in white patches.

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Community Join

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community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community At-home Testing Kit for Vitamin D deficiency?

1 upvotes 2 years ago

community Don’t like the density at all, 2nd hair transplant

in Transplants 160 upvotes 7 months ago

The user is unhappy with the results of their second hair transplant, feeling that grafts were wasted on an already transplanted hairline instead of increasing mid-scalp density. They regret stopping medications like Dutasteride, Minoxidil, and RU58841, which led to significant hair loss, and plan to restart them.

community Does anyone have a list of vitamins that could help alongside dut and min?

6 upvotes 6 months ago

The conversation is about hair loss treatments, specifically using dutasteride and oral minoxidil, and exploring additional vitamins and supplements like vitamin D, zinc, biotin, and omega-3 to support hair health. Users suggest getting a blood panel to identify deficiencies and emphasize the importance of protein and overall nutrition.

community How to improve my stack. I‘m on dut fin and ru

in Treatment 3 upvotes 7 months ago

The user is using dutasteride, finasteride, and RU58841 for hair loss but is allergic to minoxidil. Suggestions include dropping finasteride, increasing dutasteride dosage, and considering alternatives like microneedling, laser treatments, scalp massage, and supplements.

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Learn

3 / 801 results

learn Stem Cell Factor

How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.

learn C 13-15 alkane

learn Vitamin C

Is your itchy scalp a sign that it’s missing vitamin C? Find out how it may help with patchy hair loss. An itchy scalp may indicate a vitamin C deficiency affecting hair health.
Why is Vitamin C important for hair and hair follicles? Vitamin C is essential for collagen synthesis and overall hair follicle health.
Can Vitamin C help reduce hair shedding or breakage? Vitamin C may support hair health but is not a proven treatment for hair loss.
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