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GlossaryStem Cell Factor (SCF)

protein crucial for stem cell survival and differentiation

Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

26 citations, July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research Skipping of Exons by Premature Termination of Transcription and Alternative Splicing Within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant

6 citations, June 2012 in “PloS one”

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

research Expressions of bFGF, ET-1 and SCF in Dermal Papilla Cells and Their Relation to Biological Properties

1 citations, July 2004 in “PubMed”

The study found that higher levels of ET-1 and SCF in early-stage dermal papilla cells improve their ability to regenerate hair follicles.

research Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles

39 citations, January 2008 in “Journal of Endocrinology”

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

research Interaction Between Stem Cell Factor and Endothelin-1: Effects on Melanogenesis in Human Skin Xenografts

27 citations, August 2006 in “Laboratory Investigation”

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

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community Stop Complaining about Creatine. You're just fixated on shedding.

in Research/Science 76 upvotes 3 months ago

Creatine is unlikely to cause hair loss as it does not raise DHT levels. Hair loss is more likely due to genetics, medications, or lifestyle changes.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 3 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.