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    Glossary KIT Proto-Oncogene Receptor Tyrosine Kinase

    regulates cell growth and differentiation, often called c-kit

    The KIT Proto-Oncogene Receptor Tyrosine Kinase, often referred to as c-kit or CD117, is a protein that plays a crucial role in cell signaling. It is involved in the regulation of cell growth, survival, and differentiation, particularly in stem cells. Mutations in the KIT gene can lead to uncontrolled cell proliferation and are associated with various cancers, including gastrointestinal stromal tumors (GISTs).

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    1. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    2. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells International Journal of Molecular Sciences · 2023 · 1 citations
    3. Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning Frontiers in Pharmacology · 2024 · 15 citations
    4. Mechanistic Insights on Dyspepsia Modulation by Salvia rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics Processes · 2025
    5. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    6. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023 · 2 citations
    7. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    8. Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans Journal of Pharmacology and Experimental Therapeutics · 2003 · 73 citations
    9. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    10. A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression The FASEB Journal · 2000 · 96 citations
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