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    Glossary KIT Proto-Oncogene Receptor Tyrosine Kinase

    regulates cell growth and differentiation, often called c-kit

    The KIT Proto-Oncogene Receptor Tyrosine Kinase, often referred to as c-kit or CD117, is a protein that plays a crucial role in cell signaling. It is involved in the regulation of cell growth, survival, and differentiation, particularly in stem cells. Mutations in the KIT gene can lead to uncontrolled cell proliferation and are associated with various cancers, including gastrointestinal stromal tumors (GISTs).

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    1. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    2. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells International Journal of Molecular Sciences · 2023 · 1 citations
    3. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    4. Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning Frontiers in Pharmacology · 2024 · 15 citations
    5. Mechanistic Insights on Dyspepsia Modulation by Salvia rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics Processes · 2025
    6. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    7. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023 · 2 citations
    8. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    9. Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans Journal of Pharmacology and Experimental Therapeutics · 2003 · 73 citations
    10. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    11. A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression The FASEB Journal · 2000 · 96 citations
    12. Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles Journal of The American Academy of Dermatology · 2008 · 18 citations
    13. From neural crest cells to melanocytes: cellular plasticity during development and beyond Cellular and Molecular Life Sciences · 2019 · 66 citations
    14. Specific inhibition of FGF5-induced cell proliferation by RNA aptamers Scientific Reports · 2021 · 15 citations
    15. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    16. Melanocytes and Vitiligo (and Hair Graying) Elsevier eBooks · 2014 · 1 citations
    17. Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro PLOS ONE · 2019 · 6 citations
    18. Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo Journal of Investigative Dermatology · 2004 · 25 citations
    19. Cutaneous Side Effects of Chemotherapy and Radiotherapy 2016 · 2 citations
    20. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    21. Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury PLoS ONE · 2014 · 10 citations
    22. Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors (SKP) by Microarray Analysis Cellular Reprogramming · 2010 · 6 citations
    23. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study 2002 · 37 citations
    24. The involvement of androgens in human hair growth American journal of biomedical sciences · 2015 · 3 citations
    25. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells bioRxiv (Cold Spring Harbor Laboratory) · 2023
    26. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006 · 128 citations
    27. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations
    28. Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera. 1995 · 66 citations
    29. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer 2013 · 224 citations
    30. Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis Journal of Investigative Dermatology · 2023 · 3 citations