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GlossaryCaspase-1

enzyme activating inflammatory cytokines and inducing cell death

Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

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research Distribution of Caspase-14 in Epidermis and Hair Follicles Is Evolutionarily Conserved Among Mammals

21 citations , September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology”

Caspase-14 is important for skin and hair development in all mammals.

research Expression of Caspase-14 and Keratin-19 in the Human Epidermis and Appendages During Fetal Skin Development

19 citations , February 2013 in “Archives of Dermatological Research”

research Cell Death by Cornification

375 citations , June 2013 in “Biochimica et biophysica acta. Molecular cell research”

Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.

research Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

6 citations , August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

research SIG-1451: A Topical Anti-Inflammatory New Chemical Entity for Atopic Dermatitis

April 2017 in “Journal of Investigative Dermatology”

SIG-1451 could be a promising new treatment for atopic dermatitis.

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community Hair loss causes are still a myth.

in Chat 18 upvotes 4 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

community Don't use PP405 from everychem. it is likely fake.

in Research/Science 64 upvotes 4 months ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.