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    Glossary Caspase-1

    enzyme activating inflammatory cytokines and inducing cell death

    Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

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    1. Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammals 2005 · 21 citations
    2. Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions The Journal of Cell Biology · 2024 · 4 citations
    3. Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development Archives of Dermatological Research · 2013 · 19 citations
    4. 1446 RNase L acts as a regeneration suppressor Journal of Investigative Dermatology · 2023
    5. Cell death by cornification Biochimica et biophysica acta. Molecular cell research · 2013 · 375 citations
    6. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    7. Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways Frontiers in Endocrinology · 2026
    8. Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli 2025
    9. Inflammasome Proteins as Biomarkers of Injury and Disease Springer eBooks · 2014
    10. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    11. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    12. Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury Journal of radiation research · 2017 · 19 citations
    13. 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage Journal of Investigative Dermatology · 2016 · 1 citations
    14. 646 SOX4 is essential for melanoma tumorigenesis Journal of Investigative Dermatology · 2016
    15. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling PloS one · 2014 · 29 citations
    16. Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis Planta Medica · 2016 · 10 citations
    17. Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss BioMed Research International · 2018 · 9 citations
    18. Pengaruh Ekstrak Metanol Batang Etlingera alba (Blume) A. D. Poulsen Terhadap Penekanan Genicaspase-3 sebagai Penanda Apoptosis pada Lini Sel Kanker Payudara T47D Secara In Vitro Jurnal Mandala Pharmacon Indonesia · 2025
    19. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    20. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells Current Issues in Molecular Biology · 2021 · 13 citations
    21. Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways Molecules · 2026
    22. Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study International Journal of Molecular Sciences · 2024
    23. Network pharmacology analysis and experimental evaluations of YH complex on androgenetic alopecia by regulating the androgenic‐apoptotic axis 2024
    24. Androgenetische Alopezie beim Mann . Male androgenetic alopecia Zeitschrift für Hautkrankheiten · 2002 · 1 citations
    25. Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease Pharmaceuticals · 2023 · 17 citations
    26. Germinated Rhynchosia nulubilis Fermented with Lactobacillus pentosus SC65 Reduces Particulate Matter Induced Type II Alveolar Epithelial Apoptotic Cell Death International Journal of Molecular Sciences · 2021 · 13 citations
    27. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023 · 1 citations
    28. The contribution of probiotics to combined cellular therapy in skin wound healing in diabetic rats Ulusal travma dergisi · 2025 · 1 citations
    29. Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling In Vivo · 2026
    30. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue Journal of Molecular Histology · 2015 · 6 citations