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GlossaryKeratinization (Cornification)

process where skin cells produce keratin and become tough

Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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research Ultrastructural Localization of Hair Keratins, High Sulfur Keratin-Associated Proteins and Sulfhydryl Oxidase in Human Hair

9 citations , February 2016 in “Anatomical Science International”

Hair proteins change location and structure as hair cells mature.

research Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds

8 citations , January 2023 in “International journal of molecular sciences”

Transglutaminase activity is important for skin and is found in both mammals and birds.

research Inherited Disorders of Corneocyte Proteins

11 citations , January 2010 in “Current problems in dermatology”

Ichthyoses are genetic skin disorders that affect the skin's barrier function.

research Loose Anagen Hair Syndrome: A Case Study of a 6-Year-Old Girl

4 citations , April 2018 in “The journal of pediatrics/The Journal of pediatrics”

A 6-year-old girl's inability to grow her hair long was due to Loose Anagen Hair Syndrome, which causes hair to shed easily and may improve with age.

research Cell Death in Skin Function, Inflammation, and Disease

12 citations , August 2022 in “Biochemical Journal”

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

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community He is claiming, he can treat alopecia

in Chat 357 upvotes 2 months ago

A user claims a product can treat alopecia, but others are skeptical, calling it a scam due to lack of evidence and transparency. The product is said to inhibit Type II 5-αr by 22.9%, but is considered weaker than existing DHT blockers.

community Has anyone tried this Ru58841 from Amazon ?

in Product 3 upvotes 6 months ago

RU58841 from Amazon is unreliable, with users reporting no benefits and side effects like eye swelling and chest pain. Rudirect is recommended for purchasing in Europe.

community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

in Treatment 17 upvotes 5 years ago

The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

community Hair Transplant result after one week

in Progress Pictures 588 upvotes 2 years ago

The post is about a user's hair transplant results after one week, with 4000 grafts implanted. The conversation includes discussions about the healing process, shedding phase, and the number of grafts used.

community discouraged about pyrilutamide

in Research/Science 11 upvotes 3 years ago

Discouragement regarding Pyrilutamide, a drug in development for hair loss, and the potential side effects of Finasteride. People discussed anecdotal experiences with Pyrilutamide as well as suggestions to wait out Phase 3 trials before making any conclusions.

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