Epidermal Differentiation: The Role of Proteases and Their Inhibitors

The document discussed the role of proteases and their inhibitors in epidermal differentiation, highlighting their importance in maintaining the skin's barrier function. It reviewed the formation of the cornified cell envelope (CE) and its role in protecting the epidermis. The study emphasized the impact of genetic mutations affecting the CE's protein or lipid components, which can lead to dermatological diseases. It also noted the significance of a balanced protease-antiprotease system in proper epidermal and hair follicle differentiation. Key findings included the identification of SPINK5 mutations in Netherton syndrome and the role of cystatin M/E and legumain in skin and hair follicle cornification, illustrating the regulatory functions of epidermal proteases.