A Keratin Scaffold Regulates Epidermal Barrier Formation, Mitochondrial Lipid Composition, And Activity

    December 2015 in “ The Journal of Cell Biology ”
    Vinod Kumar, Jamal-Eddine Bouameur, Janina Bär … Thomas M. Magin
    Studysummary In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.
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    Research cited in this study 15

    1. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    2. Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function Cell Death and Disease · 2015
    3. Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis PeerJ · 2014
    4. Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice Journal of Biological Chemistry · 2014
    5. Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice EMBO molecular medicine · 2014
    6. Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity International review of cell and molecular biology · 2014
    7. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    8. Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis Biomolecular concepts · 2012
    9. P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis The Journal of Cell Biology · 2011
    10. Proteomic Analysis of Hair Shaft and Nail Plate PubMed · 2011
    11. Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2009
    12. Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility Nature · 2009
    13. Animal Models of Human Skin Disease Experimental Dermatology · 2004
    14. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    15. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002