Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis

    August 2014 in “ PeerJ ”
    Chelsea Laatsch, Blythe Durbin‐Johnson, David M. Rocke, Sophie Mukwana, Abby Newland, Michael J. Flagler, Michael G. Davis, Richard A. Eigenheer, Brett S. Phinney, Robert H. Rice
    TLDR Human hair proteins vary by individual, body site, and ethnicity, useful for forensics.
    The study on human hair shaft proteomic profiling revealed significant individual differences in protein expression, with keratin-associated proteins (KAPs) being particularly useful for distinguishing among ethnic groups, especially African-American samples. Hair from different body sites also showed distinct protein profiles, with scalp hair differing the most. Cuticle cells, isolated for analysis, displayed unique protein profiles compared to the total hair shaft, with notable differences in keratins and other proteins. These findings suggested potential forensic applications for hair analysis, emphasizing the need for further research to understand the genetic, environmental, and age-related factors influencing hair protein expression.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 153 results

      community Comprehensive Microneedling Guide

      in Microneedling  287 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Keratin microspheres - breakthrough

      in Research/Science  15 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  11 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Dec 2024 vs now (min + fin/dut)

      in Progress Pictures  23 upvotes 3 days ago
      The user experienced hair thickening and reduced shedding using minoxidil, finasteride, and dutasteride, with a switch from finasteride to dutasteride due to ineffectiveness. They also use a saw palmetto shampoo and take vitamin D3 supplements, while considering potential underlying causes like vitamin deficiencies and hard water buildup.

    Related Research

    4 / 4 results