Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function
February 2015
in “
Cell Death and Disease
”
AP1 transcription factor keratoderma cornified envelope keratohyalin granules keratin filaments desmosomes lamellar body secretion barrier integrity proteomic analysis RNA array analysis differentiation-associated proteins keratins hyperproliferation-associated proteins inflammation-related proteins late differentiation gene expression early differentiation gene expression AP1 factor skin barrier skin proteins skin inflammation skin differentiation
Studysummary This study found that inhibiting AP1 transcription factor activity in the suprabasal epidermis of mice alters keratinocyte gene expression, reducing barrier integrity and mimicking human keratoderma.
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