MOF-Mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

    Dongmei Wang, Haimin Li, Navdeep S. Chandel, Yali Dou, Rui Yi
    Image of study
    TLDR MOF controls skin development by regulating genes for mitochondria and cilia.
    The study investigates the role of MOF-mediated histone H4 lysine 16 acetylation (H4K16ac) in mammalian skin development. Conditional deletion of Mof, but not Kansl1, leads to severe defects in murine skin, including failure of basal epithelial progenitors to establish the basement membrane and cell polarity, resulting in compromised self-renewal, epidermal differentiation, and hair growth, ultimately causing barrier defects and perinatal lethality. MOF-regulated genes are enriched in mitochondrial and ciliary functions, coordinated with the RFX2 transcription factor. Deletion of Uqcrq, a key subunit of ETC Complex III, mimics the defects seen in MOF cKO, highlighting the critical role of the MOF/ETC axis in skin development.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 22 results

      community Why don’t people just just DUT instead of FIN?

      in Finasteride/Dutasteride  48 upvotes 1 year ago
      The conversation discusses the use of dutasteride (DUT) versus finasteride (FIN) for hair loss treatment, with some users preferring DUT for its effectiveness while others choose FIN due to its approval status, better long-term data, and lower risk of side effects. Users share personal experiences with both medications, including side effects and effectiveness.

      community Don't give up! 9 months on Minoxidil

      in Progress Pictures  392 upvotes 11 months ago
      A trans man shared progress pictures showing significant hair regrowth after 9 months on oral Minoxidil and 1.5 years on finasteride. He encourages others to stick with their treatments despite initial setbacks.

      community FTM/NB Hairloss from HRT, treatment started and feeling hopeless.

      in Transgender  61 upvotes 1 week ago
      A non-binary individual experienced hair loss after stopping hormone replacement therapy and is using oral Dutasteride, oral Minoxidil, and ketoconazole shampoo. They are hopeful for regrowth but may use wigs due to the high cost and uncertain effectiveness of additional treatments like mesotherapy and PRP.

      community Need advice whether on starting Fin

      in General  217 upvotes 1 week ago
      The user is considering starting finasteride for hair loss prevention, expressing concerns about potential side effects like reduced libido and erectile dysfunction. They are currently taking saw palmetto, vitamin D, zinc, vitamin C, and biotin but are unsure if these will be effective.

    Similar Research

    5 / 450 results