Hair Follicle Stem Cell Fate Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation

    December 2017 in “ Stem cells ”
    Nadine Schuler, Sara Timm, Claudia E. Rübe
    Studysummary This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.
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    Research cited in this study 8

    1. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    4. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    5. Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation PLoS ONE · 2007
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    7. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    8. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001