Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation

The study investigated the role of the phosphatase regulator NIPP1 in controlling chemokine-driven skin inflammation and found that NIPP1 was crucial for maintaining skin homeostasis by modulating chemokine signaling pathways. Deletion of NIPP1 in mouse epidermis led to significant skin inflammation, epidermal hyperproliferation, and hair loss due to increased expression of pro-inflammatory chemokines and reduced adherence and stemness of hair follicle stem cells (HFSCs). These effects were partially mitigated by dexamethasone treatment. The findings suggested that NIPP1 could be a potential therapeutic target for treating inflammatory skin diseases, highlighting its role in restraining inflammatory responses and maintaining skin homeostasis.