Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis
March 2024
in “
International journal of molecular sciences
”
radiation dermatitis ionizing radiation DNA damage epidermal keratinocytes cellular senescence pro-inflammatory mediators skin inflammation immune cell recruitment neutrophils IL-17-expressing γδ-T cells hyperproliferation epidermal barrier dysfunction hair loss alopecia radiotherapy immunomodulatory treatments radiation therapy skin cells cell aging inflammatory mediators immune cells white blood cells IL-17 T cells skin overgrowth skin barrier dysfunction baldness immune treatments
Studysummary This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.
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