Human αβ and γδ T Cells in Skin Immunity and Disease

The document reviewed the functions of αβ and γδ T cells in maintaining skin homeostasis and their roles in skin immunity and disease. It highlighted that while αβ T cells have been widely studied, γδ T cells are often overlooked despite their critical role in balancing keratinocyte differentiation and proliferation against the destruction of infected or malignant cells. The review emphasized the importance of these T cells in skin health and their involvement in diseases such as psoriasis and alopecia areata. It also pointed out that an imbalance in T cell function can lead to autoimmune diseases, hinder tumor eradication, or impair wound healing. The document suggested that understanding the interactions between T cell populations and other immune cells is crucial for developing new treatments for skin conditions, but acknowledged that more research is needed to effectively manage T cell function for maintaining skin health.