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GlossaryIonizing Radiation

high-energy particles or waves that can remove electrons from atoms

Ionizing radiation (IR) refers to high-energy particles or waves, such as X-rays, gamma rays, and certain particles, that have enough energy to remove tightly bound electrons from atoms, creating ions. This process can damage or alter the DNA in cells, which is why it is used in medical imaging and cancer treatment, but also why it poses risks such as radiation sickness and increased cancer risk with excessive exposure.

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research Cell and Tissue Damage After Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects After Single and Fractional Doses

14 citations , January 2014 in “Cells Tissues Organs”

Ionizing radiation causes irreversible skin damage, with single doses leading to acute injury and hair graying, and fractional doses causing more severe long-term tissue damage.

research Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

4 citations , August 2022 in “International Journal of Molecular Sciences”

Human foreskin does not show aging or reduced cell growth after radiation, and H2A.J is not a good marker for radiation-induced aging.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage

3 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

research A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation

2 citations , January 2016 in “Sarcoma”

Inducing survivin in normal tissues can protect against radiation damage.

research Effects of Ionizing Radiation on Murine Gene Expression in Skin and Bone

January 2017 in “NASA Technical Reports Server (NASA)”

Early changes in skin gene expression can predict later bone mass loss after radiation exposure.

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