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GlossaryHydroxyl Radicals

highly reactive molecules damaging cells and DNA

Hydroxyl radicals (OH radicals) are highly reactive molecules that contain one oxygen and one hydrogen atom. They are often formed during the breakdown of water molecules by ultraviolet light or through certain chemical reactions. In biological systems, hydroxyl radicals can cause significant damage to cells, proteins, and DNA, contributing to aging and various diseases, including those affecting hair health and potentially leading to conditions like alopecia.

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research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations, May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

research Ultrasonic-Assisted Extraction and In-Vitro Antioxidant Activity of Polysaccharide from Hibiscus Leaf

59 citations, August 2014 in “International Journal of Biological Macromolecules”

The study found an efficient method to extract antioxidants from Hibiscus leaves.

research Prooxidant And Antioxidant Action Of 4-(4-Phenoxybenzoyl)benzoic Acid Derivatives

2 citations, February 2004 in “Biopolymers”

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

research Mackerel Fermented Fish Oil Suppresses Human Keratinocyte Damage Caused by Ultraviolet B Radiation

September 2017 in “Journal of Investigative Dermatology”

Mackerel fermented fish oil protects skin cells from damage by UVB light.

research Recovery Effects of Active Oxygen Scavengers on Murine Hair Follicle-Derived Keratinocyte Proliferation Suppressed by Androgen

August 1994 in “Journal of dermatological science”

Active oxygen scavengers can reverse the suppression of hair cell growth caused by androgens.

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community Looking to make my own 2-Deoxy-D-ribose. Any science bros can give advice?

in Research/Science 7 upvotes 4 months ago

A user is making a 2-Deoxy-D-ribose solution and asks if it can be put into an oil instead of a gel, considering adding hydrocortisone and retinoic acid. They seek advice on the best carrier oil for hair growth.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community 6 Month Progress Pics - Dutasteride

in Progress Pictures 140 upvotes 1 year ago

The conversation discusses hair loss and the use of Dutasteride for treatment. One participant strongly supports the use of Dutasteride.

community Help needed with finding an alternative to my dermatologist's recommendation ( shampoo and conditioner)

6 years ago

A user is seeking alternatives to **Curatio Triclenz Hair Cleanser** and **Triflow Hair Conditioner** due to issues with hair weight and scalp pimples. They need recommendations for mild shampoos available in Europe, preferably Sweden.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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