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    Glossary Hydroxyl Radicals

    highly reactive molecules damaging cells and DNA

    Hydroxyl radicals (OH radicals) are highly reactive molecules that contain one oxygen and one hydrogen atom. They are often formed during the breakdown of water molecules by ultraviolet light or through certain chemical reactions. In biological systems, hydroxyl radicals can cause significant damage to cells, proteins, and DNA, contributing to aging and various diseases, including those affecting hair health and potentially leading to conditions like alopecia.

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    1. Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism APOPTOSIS · 2011 · 52 citations
    2. Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata Annals of Dermatology · 2014 · 12 citations
    3. Ultrasonic-assisted extraction and in-vitro antioxidant activity of polysaccharide from Hibiscus leaf International Journal of Biological Macromolecules · 2014 · 59 citations
    4. Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors PLOS ONE · 2014 · 46 citations
    5. Mechanism of Cuticle Hole Development in Human Hair Due to UV-Radiation Exposure Cosmetics · 2018 · 8 citations
    6. Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives Biopolymers · 2004 · 2 citations
    7. Hair colouring systems delivering colour with reduced fibre damage International Journal of Cosmetic Science · 2008 · 1 citations
    8. Acetyl zingerone methyl ether protects hair against oxidative damage incurred during and after treatment with permanent dyes and helps extend longevity of newly developed hair colour International Journal of Cosmetic Science · 2024
    9. 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation Journal of Investigative Dermatology · 2017
    10. Recovery effects of active oxygen scavengers on murine hair follicle-derived keratinocyte proliferation suppressed by androgen Journal of dermatological science · 1994
    11. CORRELATION IN HAIR GROWTH AND ANTIOXIDANT ACTIVITY OF SOME HIMALAYAN MEDICINAL PLANTS 2012
    12. PHENOLIC COMPOUND CONTENT, ANTIOXIDANT AND RADICAL-SCAVENGING PROPERTIES OF METHANOLIC EXTRACTS FROM THE SEED COAT OF CERTAIN THAI TAMARIND CULTIVARS Journal of Food Biochemistry · 2010 · 10 citations
    13. 신선육자환 에탄올 추출물의 항산화 활성 대한본초학회지(본초분과학회지) · 2017
    14. Exploring the Antioxidant Potential of Blackberry and Raspberry Leaves: Phytochemical Analysis, Scavenging Activity, and In Vitro Polyphenol Bioaccessibility Antioxidants · 2023 · 12 citations
    15. A fast and simple FIA-chemiluminescence method for the evaluation of Roselle flowers as scavenger of the free radicals generated by UV irradiated antibiotics Journal of Pharmaceutical and Biomedical Analysis · 2018 · 4 citations
    16. Phytoconstituents and Antioxidant Profiling of Avicennia marina (Forsk.) Vierh. Heartwood Extract Sourced from Bagan Kuala: A Novel Natural Source for Radical Scavenging Applications Journal of Sylva Indonesiana · 2026
    17. Protective Effects of Zizyphus jujuba and Fermented Zizyphus jujuba from Free Radicals and Hair Loss Journal of The Korean Society of Food Science and Nutrition · 2014 · 9 citations
    18. Flavonoids with Two OH Groups in the B-Ring Promote Pigmented Hair Regeneration Biological & Pharmaceutical Bulletin · 2019 · 13 citations
    19. Extraction of phenolic compounds and evaluation of the antioxidant and phenolic compounds of onion (Allium cepa L.) Journal of Pharmacognosy and Phytochemistry · 2019 · 1 citations
    20. Pharmacological and Phytochemical Updates on Citrullus colocynthis & Citrullus lanata Indo global journal of pharmaceutical sciences · 2020 · 1 citations
    21. Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review Frontiers in Pharmacology · 2026
    22. A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives Molecules · 2020 · 2 citations
    23. Steroid 5α-reductase inhibition by polymethoxyflavones 한국응용생명화학회지 · 2013 · 6 citations
    24. Indole-based derivatives effect on rats with polycystic ovary syndrome Journal of Pharmaceutical Investigation · 2017
    25. Skin Ageing in Women: Pathophysiology and Treatment The Journal of The British Menopause Society · 1999
    26. Synergistic antioxidant-antimicrobial-immunomodulatory self-healing “radical sponge” hydrogel for diabetic wound regeneration via microenvironment reprogramming mediated by coordinated MAPK suppression and PI3K-AKT activation Chemical Engineering Journal · 2026
    27. Antioxidant Constituents of Hops (Humulus lupulus L.) as Functional Raw Materials for Cosmetic Applications Materials · 2026
    28. Fullerene C<sub>60</sub> with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in Dermatology? Experimental Dermatology · 2016 · 35 citations
    29. Effects of Copper (II) Albumin Complex on Thermal Skin Burn Bulletin of Egyptian Society for Physiological Sciences · 2012
    30. Current advances of <i>Dendrobium officinale</i> polysaccharides in dermatology: a literature review Pharmaceutical Biology · 2020 · 45 citations