Hydrogen Peroxide and Wound Healing

    June 2008 in “ Dermatologic Surgery ”
    Sara Wasserbauer, David Pérez-Meza, Ron Chao
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    TLDR Hydrogen peroxide may have both positive and negative effects on wound healing, and its safe concentration for hair transplant surgery is unclear.
    The document reviewed the role of hydrogen peroxide (H₂O₂) in wound healing, particularly in the context of hair transplant surgery, and found mixed evidence regarding its efficacy and safety. While H₂O₂ has been shown to have some positive effects, such as stimulating growth factors and fibroblast proliferation, it also exhibits negative impacts, including cytotoxicity and inhibition of keratinocyte migration. The review highlighted that the optimal concentration of H₂O₂ for hair restoration surgery is unknown due to the limited number of studies, which lack conclusive evidence. It was noted that concentrations less than or equal to 700 µM might be less harmful, but the overall conclusion was that H₂O₂ can induce apoptosis and has multiple inhibitory effects on wound healing. The document recommended caution in the use of H₂O₂ in hair transplant surgery and called for further research to determine safe and effective concentrations.
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