Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

    May 2011 in “ APOPTOSIS ”
    Sudjit Luanpitpong, Ubonthip Nimmannit, Pithi Chanvorachote … Yon Rojanasakul
    Studysummary In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.
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    Research cited in this study 6

    1. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    2. Prevention of Chemotherapy-Induced Alopecia in Rodent Models Cell stress & chaperones · 2008
    3. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    4. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    5. Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes Journal of dermatological science · 2000
    6. Hair Follicle Apoptosis And Bcl-2 Journal of Investigative Dermatology Symposium Proceedings · 1999