Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism
May 2011
in “
APOPTOSIS
”
TLDR Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.
The study concluded that cisplatin induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through the generation of hydroxyl radicals, which triggered a Bcl-2-dependent mechanism. This involved the down-regulation of the anti-apoptotic protein Bcl-2 and the up-regulation of the pro-apoptotic protein Bax. The role of hydroxyl radicals was confirmed by the inhibition of apoptosis using antioxidants. These findings provided insights into the molecular pathways of hair follicle damage during chemotherapy and suggested potential therapeutic strategies to mitigate chemotherapy-induced alopecia by targeting ROS pathways.
