Hair Growth-Promoting Mechanisms of Red Ginseng Extract Through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health

The study demonstrated that Red Ginseng Extract (RGE) promotes hair growth and improves skin health. It was found to stimulate the proliferation of dermal papilla cells, induce early progression of hair follicles into the anagen phase, and activate the Wnt/β-catenin pathway. RGE treatment also increased skin thickness, hair bulb size, and stimulated hair regrowth in mice. It enhanced the antioxidant defense system in mouse skin, regulated apoptosis, and increased levels of growth factors VEGF and IGF-1, and markers of anagen in growing hair, ALP and γ-GT. Furthermore, RGE treatment significantly increased phosphorylation of ERK and Akt, which are involved in the regulation of dermal papilla cell proliferation in hair follicles. These findings suggest that RGE could be a potent therapeutic agent for prevention and/or treatment of hair loss.