Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads

    April 2022 in “ Journal of Bioscience and Bioengineering ”
    Monami Yamane, Jieun Seo, Yinghui Zhou … Junji Fukuda
    Studysummary This study found that activating the PI3K/Akt signaling pathway in dermal papilla cells enhances their hair-inducing capabilities, suggesting potential strategies for hair regenerative medicine.
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    Research cited in this study 23

    1. Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2022
    2. TGF-β2 and Collagen Play Pivotal Roles in the Spheroid Formation and Anti-Aging of Human Dermal Papilla Cells Aging · 2021
    3. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2021
    4. Impact of Adipose-Derived Stem Cells on Engineering Hair Follicle Germ-Like Tissue Grafts for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2021
    5. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    6. Effects of Platelet-Rich Plasma on In Vitro Hair Follicle Germ Preparation for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2020
    7. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    8. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    9. Use of Extracellular Matrix Hydrogel from Human Placenta to Restore Hair-Inductive Potential of Dermal Papilla Cells Regenerative Medicine · 2019
    10. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    11. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    12. Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells in Vivo · 2019
    13. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    14. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    15. Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway Experimental Dermatology · 2015
    16. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    17. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    18. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    19. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    20. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    21. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    22. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    23. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004

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