Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells

July 2019 in “ in Vivo ”

Napapat Rattanachitthawat, Tatchakorn Pinkhien, Praneet Opanasopit, Tanasait Ngawhirunpat, Pithi Chanvorachote

finasteride stem cell signals human dermal papilla cells AKT protein ß-catenin transcription factors Sox-2 Nanog self-renewal properties hair growth Propecia

TLDR Finasteride boosts stem cell signals for hair growth.

A study from 2019 found that finasteride, a drug used to treat hair loss, enhances stem cell signals in human dermal papilla cells. The drug activates the AKT protein, which increases cellular levels of ß-catenin, a key regulator of stem cell signaling. This results in the induction of transcription factors such as Sox-2 and Nanog, which are important for self-renewal properties of stem cells. The study suggests that finasteride may have therapeutic and cosmeceutical applications for hair growth.

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