Glycyrrhizic Acid Attenuates Stem Cell-Like Phenotypes of Human Dermal Papilla Cells
November 2015
in “
Phytomedicine
”
Research cited in this study
3 / 3 resultsresearch Topically Applied Glycyrrhizic Acid Causes Hair Removal in Rats
The study investigated the effects of topically applied glycyrrhizic acid, derived from sweet licorice, on hair removal in Wistar rats. A solution containing 15% glycyrrhizic acid was applied twice daily, resulting in 20-30% hair removal after 3 days and 90-95% after 6-12 days. Long-term treatment over 9 months showed no inflammation and reduced hair regrowth by about 20%. Scanning electron microscopy indicated a smoothed hair cuticle, aiding hair shaft detachment. The findings suggested glycyrrhizic acid as a potential treatment for hypertrichosis in humans.
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Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.
research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
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