Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway

The study demonstrated that loliolide, a monoterpenoid found in algae, enhanced the hair growth-inductive properties of human dermal papilla (HDP) cells by activating the Akt/β-catenin signaling pathway. Using a 3D spheroid model, researchers found that loliolide increased the viability and size of HDP spheroids, correlating with higher expression levels of hair growth-related factors such as VEGF, IGF-1, and KGF. Loliolide treatment also promoted the expression of DP signature genes and enhanced keratinocyte proliferation. These findings suggested that loliolide could be a potential therapeutic candidate for treating alopecia by enhancing hair follicle inductivity through specific signaling pathways.