Use of Extracellular Matrix Hydrogel from Human Placenta to Restore Hair-Inductive Potential of Dermal Papilla Cells

    August 2019 in “ Regenerative Medicine ”
    Xinyu Zhang, Shan Xiao, Bingcheng Liu … Zhiqi Hu
    Studysummary This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.
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    Research cited in this study 25

    1. Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration Advanced Healthcare Materials · 2017
    2. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    3. Effects of Extracellular Matrix on the Growth Characteristics of Human Dermal Papillae Cells In Vitro Clinical and Experimental Dermatology · 2016
    4. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    5. Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells International Journal of Molecular Medicine · 2015
    6. Potential Synergistic Effects of Human Placental Extract and Minoxidil on Hair Growth-Promoting Activity in C57BL/6J Mice Clinical and Experimental Dermatology · 2015
    7. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014
    8. A Role of Placental Growth Factor in Hair Growth Journal of dermatological science · 2014
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    10. Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo Dermatologic Surgery · 2013
    11. Future Horizons in Hair Restoration Facial Plastic Surgery Clinics of North America · 2013
    12. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    13. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    14. Treatment Options for Alopecia: An Update, Looking to the Future Expert Opinion on Pharmacotherapy · 2012
    15. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    16. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012
    17. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011
    18. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    19. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    20. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    21. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    22. Bioengineering the Hair Follicle Organogenesis · 2007
    23. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    24. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    25. Dermal-Epidermal Interactions in Hair Follicle Development and Cycling Clinics in dermatology · 1988

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