Potential Synergistic Effects of Human Placental Extract and Minoxidil on Hair Growth-Promoting Activity in C57BL/6J Mice

August 2015 in “ Clinical and Experimental Dermatology ”

Tae Gyun Kwon, Choo Hiap Oh, H. Park, H. Han, H. J. Ji, Bobae Kim

human placental extract minoxidil hair growth C57BL/6J mice skin thickness hair follicles anagen stage Wnt/ß-catenin pathway HPE MXD Rogaine

TLDR Human placental extract and minoxidil together significantly promote hair growth.

In 2015, a study was conducted on C57BL/6J mice to assess the combined effects of human placental extract (HPE) and minoxidil (MXD) on hair growth. The results showed that the combination of HPE and MXD significantly promoted hair growth, with the HPE + MXD group showing increased skin thickness, more hair follicles, and more frequent anagen (growth) stage hair compared to the normal group. The mean hair follicle counts for the HPE + MXD group were 139.75 ± 6.70, compared to 112.63 ± 6.87 for the 2% MXD group. The study suggested that HPE stimulates early embryonic development of hair and significantly affects hair follicle development through the Wnt/ß-catenin pathway. This suggested that HPE could potentially be a treatment for hair loss.

View this study on academic.oup.com →

Discuss this study in the Community →

Cited in this study

11 / 11 results

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

63 citations , December 2013 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.

research Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations , May 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Cow Placenta Extract Promotes Murine Hair Growth Through Enhancing the Insulin-Like Growth Factor-1

22 citations , January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology”

Cow placenta extract may help hair grow by increasing a growth factor but is less effective than minoxidil.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations , June 2005 in “Genes & development”

β-catenin is essential for stem cell activation and proliferation in hair follicles.

research Management of Androgenetic Alopecia

22 citations , May 2000 in “American Journal of Clinical Dermatology”

Treatments for common hair loss include minoxidil, finasteride, and hair transplantation.

research Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women

145 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride 1mg helps reverse hair miniaturization in men and postmenopausal women.

research Finasteride

125 citations , January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research Hair loss

12 citations , May 1989 in “Postgraduate Medicine”

The document concludes that hair loss is common and can be treated with medications like minoxidil or surgical options, and it significantly affects people's psychological well-being.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.

8 / 8 results

research Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia

7 citations , March 2022 in “International Journal of Pharmaceutics”

Safflower oil nanoparticles can deliver hFGF10 to hair follicles, reduce inflammation, and potentially speed up hair growth in conditions causing hair loss.

research Effects of Crataegi Fructus Water Extract on Hair Growth and Gene Expression in Dermal Papilla Cells

September 2017 in “Korean journal of acupuncture”

Crataegi Fructus water extract helps hair grow better and thicker.

research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

1 citations , January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

1 citations , September 2016 in “Journal of Investigative Dermatology”

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

research Potential Synergistic Effects of Human Placental Extract and Minoxidil on Hair Growth-Promoting Activity in C57BL/6J Mice

14 citations , August 2015 in “Clinical and Experimental Dermatology”

Human placental extract and minoxidil together significantly promote hair growth.

research Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues

3 citations , March 2015 in “Biomolecules & Therapeutics”

Phospholipids from pig lungs can significantly promote hair growth.

research FCP 3: Platelet-Rich Plasma Induced Hair Growth in Alopecia Patients Partially Through Dermal Papilla Cell Proliferation, BCl-2 and KGF Up-Regulation

January 2014 in “프로그램북(구 초록집)”

Platelet-rich plasma treatments help hair growth in people with hair loss by increasing certain cell growth and protein levels.

research Studies on the Effects of Medicinal Plant Extracts on Hair Growth Stimulation

1 citations , January 2002 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology”

Some plant extracts may help hair grow.