STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing
August 2016
in “
Journal of Investigative Dermatology
”
STAT5 activation dermal papilla hair follicle growth phase hair follicle regeneration wound healing olfactory receptors OR2AT4 Sandalore alopecia areata AA Maraviroc CCR5 inhibitor CD73 anagen-prolonging adenosine hair follicle epithelium mesenchymal switch anagen entry hair follicle cycling hair growth hair loss hair regeneration smell receptors odorant HIV drug enzyme growth phase autoimmune disease
TLDR Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.
The document from 7 years ago discusses four different studies related to hair growth and hair loss. The first study found that human hair follicles can "smell" through olfactory receptors (OR), specifically OR2AT4, which regulates hair follicle growth. The study suggests that the odorant, Sandalore, could potentially be used as a therapy for managing hair growth disorders. The second study focused on the treatment of alopecia areata (AA), an autoimmune disease causing hair loss. The study found that the HIV drug Maraviroc, a CCR5 inhibitor, improved hair loss in 4 out of 5 mice with AA. The third study revealed that the enzyme CD73 regulates human hair growth by modulating the production of anagen-prolonging adenosine within the hair follicle epithelium. The final study found that STAT5 activation in the dermal papilla (DP) is crucial for hair follicle growth phase induction, hair follicle regeneration, and wound healing. The study concluded that STAT5 activation acts as a mesenchymal switch to trigger natural anagen entry in post-developmental hair follicle cycling.
