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    Glossary OR2AT4

    gene encoding an olfactory receptor influencing hair growth

    OR2AT4 is a gene that encodes a specific type of olfactory receptor, which is typically involved in the sense of smell. Interestingly, research has shown that this receptor is also present in human hair follicles and can influence hair growth when activated by certain compounds, such as Sandalore, a synthetic sandalwood odorant. This discovery has potential implications for treating conditions like alopecia, where hair growth is impaired.

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    Research 10 of 54

    1. OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes Antioxidants · 2022 · 6 citations
    2. 181 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial Journal of Investigative Dermatology · 2019
    3. 609 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates female telogen effluvium: Randomized, double-blinded, placebo-controlled clinical trial Journal of Investigative Dermatology · 2019
    4. 495 OR2AT4 activation by a synthetic odorant, stimulates dermcidin production in human hair follicle epithelium and increases follicular resistance to bacterial contamination: A novel antimicrobial folliculitis therapy? 2019
    5. 216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation Journal of Investigative Dermatology · 2016
    6. Treatment With Cyclohexyl Salicylate, an OR2A4 /7 Agonist, Promotes Hair Growth and the Expansion of Epithelial Progenitor Cells in Human Hair Follicles Ex Vivo Experimental Dermatology · 2026
    7. Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion Molecular Therapy — Nucleic Acids · 2025
    8. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    9. Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore<sup>®</sup>, improves telogen effluvium‐associated parameters Journal of Cosmetic Dermatology · 2020 · 11 citations
    10. 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing Journal of Investigative Dermatology · 2016 · 1 citations
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