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Glossary OR2AT4

gene encoding an olfactory receptor influencing hair growth

OR2AT4 is a gene that encodes a specific type of olfactory receptor, which is typically involved in the sense of smell. Interestingly, research has shown that this receptor is also present in human hair follicles and can influence hair growth when activated by certain compounds, such as Sandalore, a synthetic sandalwood odorant. This discovery has potential implications for treating conditions like alopecia, where hair growth is impaired.

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Sandalore

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research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

6 citations , November 2022 in “Antioxidants”

In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.

research 181 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial

September 2019 in “Journal of Investigative Dermatology”

This clinical trial found that Sandalore® 1% significantly reduced hair shedding and increased hair volume and anagen hair follicles in women with telogen effluvium compared to placebo.

research 609 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates female telogen effluvium: Randomized, double-blinded, placebo-controlled clinical trial

April 2019 in “Journal of Investigative Dermatology”

This clinical trial found that topical application of Sandalore® 1% significantly reduced hair shedding and increased hair volume in women with telogen effluvium compared to placebo.

research 495 OR2AT4 activation by a synthetic odorant, stimulates dermcidin production in human hair follicle epithelium and increases follicular resistance to bacterial contamination: A novel antimicrobial folliculitis therapy?

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that stimulating olfactory receptors in human hair follicles with Sandalore® increases antimicrobial activity by upregulating dermcidin production, potentially offering a novel approach for treating hair follicle diseases with bacterial issues.

research 216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation

August 2016 in “Journal of Investigative Dermatology”

This study found that stimulating olfactory receptor OR2AT4 in human hair follicles with Sandalore® may slow catagen development and reduce keratinocyte apoptosis, suggesting potential implications for hair growth management.

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