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    Glossary OR2AT4

    gene encoding an olfactory receptor influencing hair growth

    OR2AT4 is a gene that encodes a specific type of olfactory receptor, which is typically involved in the sense of smell. Interestingly, research has shown that this receptor is also present in human hair follicles and can influence hair growth when activated by certain compounds, such as Sandalore, a synthetic sandalwood odorant. This discovery has potential implications for treating conditions like alopecia, where hair growth is impaired.

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    Research 30 of 54

    1. OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes Antioxidants · 2022 · 6 citations
    2. 181 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial Journal of Investigative Dermatology · 2019
    3. 609 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates female telogen effluvium: Randomized, double-blinded, placebo-controlled clinical trial Journal of Investigative Dermatology · 2019
    4. 495 OR2AT4 activation by a synthetic odorant, stimulates dermcidin production in human hair follicle epithelium and increases follicular resistance to bacterial contamination: A novel antimicrobial folliculitis therapy? 2019
    5. 216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation Journal of Investigative Dermatology · 2016
    6. Treatment With Cyclohexyl Salicylate, an OR2A4 /7 Agonist, Promotes Hair Growth and the Expansion of Epithelial Progenitor Cells in Human Hair Follicles Ex Vivo Experimental Dermatology · 2026
    7. Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion Molecular Therapy — Nucleic Acids · 2025
    8. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    9. Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore<sup>®</sup>, improves telogen effluvium‐associated parameters Journal of Cosmetic Dermatology · 2020 · 11 citations
    10. 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing Journal of Investigative Dermatology · 2016 · 1 citations
    11. 525 Aptamer-Based Targeted Therapy for wound healing and hair growth promotion Journal of Investigative Dermatology · 2024
    12. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    13. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    14. 217 The adenosine-generating ecto-enzyme CD73 regulates human hair growth Journal of Investigative Dermatology · 2016
    15. 184 WITHDRAWN Journal of Investigative Dermatology · 2019
    16. 185 Infrared and high frequency ultrasound imaging of skin lesions in atopic dermatitis and psoriasis vulgaris Journal of Investigative Dermatology · 2019
    17. 182 Retinol remarkably effective in reducing neck wrinkles Journal of Investigative Dermatology · 2019
    18. Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients Experimental Dermatology · 2021 · 18 citations
    19. Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo PLoS ONE · 2019 · 27 citations
    20. Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options Expert Opinion on Therapeutic Targets · 2019 · 19 citations
    21. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 8 citations
    22. A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? Biomedicines · 2021 · 4 citations
    23. <i>Brassica oleracea</i> extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo Journal of Cosmetic Dermatology · 2021 · 2 citations
    24. 608 A clinical study to test the efficacy of VB1953 in clindamycin non-responder acne patients with antibiotic-resistant P. acnes Journal of Investigative Dermatology · 2019 · 1 citations
    25. 605 Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis Journal of Investigative Dermatology · 2019 · 1 citations
    26. 606 The role of diet in patients with autoimmune blistering disease: A survey of the International Pemphigus and Pemphigoid Foundation Journal of Investigative Dermatology · 2019
    27. 503 A new chemosensory control of human hair growth: Olfactory receptor OR10J1 stimulation promotes scalp hair follicle growth and progenitor cell generation ex vivo Journal of Investigative Dermatology · 2024
    28. New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies Italian journal of dermatology and venereology · 2018 · 3 citations
    29. 568 Novel synthetic melanin nanoparticles improve skin wound healing Journal of Investigative Dermatology · 2024
    30. Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System 2019 · 142 citations