OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

    November 2022 in “ Antioxidants ”
    Ji-Sun Kim, Ha Lim Lee, Ji Hyun Jeong … Sung-Joon Lee
    Studysummary In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.
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    Research cited in this study 3

    1. Ectopic Odorant Receptors Responding to Flavor Compounds in Skin Health and Disease: Current Insights and Future Perspectives Critical reviews in food science and nutrition · 2022
    2. Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore, Improves Telogen Effluvium-Associated Parameters Journal of Cosmetic Dermatology · 2020
    3. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018