Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore, Improves Telogen Effluvium-Associated Parameters

    Francisco Jiménez, Esmeralda López, Marta Bertolini, Majid Alam, Jérémy Chéret, Gillian Westgate, Fabio Rinaldi, Barbara Mora, Ralf Paus
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    TLDR Sandalore® improves hair growth and quality in people with hair loss.
    The study demonstrated that the topical application of Sandalore®, an agonist of the olfactory receptor OR2AT4, significantly improved parameters associated with telogen effluvium, a form of hair loss. Participants reported decreased hair shedding, increased hair growth, stronger and denser hair, and overall better hair quality. Objective measurements confirmed these improvements, showing significant increases in hair volume, the ratio of terminal to vellus hairs, and the percentage of anagen (growth phase) hair follicles. The findings suggested that Sandalore® could be an effective treatment for telogen effluvium, highlighting the potential of olfactory receptor agonists in hair growth and hair loss treatments.
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