TLDR Skin odorant receptors respond to flavors and could be targeted to improve skin health and treat diseases.
This review explores the role of ectopic odorant receptors (ORs) in skin health and disease, highlighting their activation by flavor compounds from food and plant essential oils. ORs, found in skin cells like keratinocytes, melanocytes, and fibroblasts, are involved in various skin processes such as wound healing, hair growth, melanin regulation, and conditions like atopic dermatitis and psoriasis. The study emphasizes the potential of targeting skin ORs with flavor compounds as a novel therapeutic strategy, given their classification as highly druggable G protein-coupled receptors.
Cited in this study
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147 citations
,
November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
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,
November 2020 in “Molecules” Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.
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,
July 2020 in “Journal of Cosmetic Dermatology” Sandalore® improves hair growth and quality in people with hair loss.
67 citations
,
December 2019 in “PloS one” Beta-caryophyllene helps improve wound healing in mice, especially in females.
176 citations
,
June 2019 in “Cells” Different fibroblasts play key roles in skin healing and scarring.
269 citations
,
December 2018 in “International journal of biological macromolecules” Hyaluronic acid is effective for skin rejuvenation and should be a key ingredient in cosmetic products.
82 citations
,
September 2018 in “Nature Communications” A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.
32 citations
,
June 2015 in “PLOS ONE” Olive leaf compound oleuropein helps grow hair in mice.
