TLDR Skin odorant receptors respond to flavors and could be targeted to improve skin health and treat diseases.
This review explores the role of ectopic odorant receptors (ORs) in skin health and disease, highlighting their activation by flavor compounds from food and plant essential oils. ORs, found in skin cells like keratinocytes, melanocytes, and fibroblasts, are involved in various skin processes such as wound healing, hair growth, melanin regulation, and conditions like atopic dermatitis and psoriasis. The study emphasizes the potential of targeting skin ORs with flavor compounds as a novel therapeutic strategy, given their classification as highly druggable G protein-coupled receptors.
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