Regeneration of Dermis: Scarring and Cells Involved

    June 2019 in “ Cells ”
    A. Rippa, Ekaterina P. Kalabusheva, E. A. Vorotelyak
    TLDR Different fibroblasts play key roles in skin healing and scarring.
    The document discussed the regeneration of the dermis, focusing on scarring and the cells involved. It highlighted the roles of different fibroblast populations, particularly papillary and reticular fibroblasts, in skin morphogenesis, homeostasis, and wound healing. The studies reviewed indicated that fibroblast heterogeneity significantly impacted dermal architecture and repair processes. Additionally, the document explored the potential of dermal papilla cells in hair follicle regeneration and their contribution to wound healing. Key findings included the role of angiogenin in stimulating hair growth, the importance of Fgf20 in hair follicle development, and the impact of β-catenin signaling on fibrosis and hair follicle regeneration. The document also discussed the differential gene expression and behavior of fibroblasts in keloid versus normal dermal tissue, emphasizing the role of myofibroblasts, collagen production, and the epithelial-mesenchymal transition (EMT) in abnormal wound healing. Various studies were cited, demonstrating the impact of growth factors like TGF-β and the mechanical properties of the extracellular matrix on fibroblast activity. The potential of hyaluronic acid-based treatments for wound healing and the challenges in treating keloids and hypertrophic scars were also explored. Overall, the research underscored the complexity of dermal regeneration and the potential for targeted therapies to improve healing and reduce scarring.
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