Regeneration of Dermis: Scarring and Cells Involved

    June 2019 in “ Cells ”
    A. Rippa, Ekaterina P. Kalabusheva, E. A. Vorotelyak
    Studysummary This review discusses dermal cell heterogeneity in wound healing and scar formation, highlighting the varied roles of different fibroblasts and the potential of skin substitutes without presenting new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 38

    1. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    2. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    3. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    4. Hyaluronic Acid-Based Hydrogels for Full-Thickness Wound Repairing and Skin Regeneration Journal of Materials Science: Materials in Medicine · 2018
    5. Engineering Pro-Regenerative Hydrogels for Scarless Wound Healing Advanced Healthcare Materials · 2018
    6. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    7. Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin Biomaterials · 2018
    8. Mechanical Forces in Skin Disorders Journal of Dermatological Science · 2018
    9. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    10. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    11. Pro-Regenerative Hydrogel Restores Scarless Skin During Cutaneous Wound Healing Advanced Healthcare Materials · 2017
    12. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    13. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    14. Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins British journal of dermatology/British journal of dermatology, Supplement · 2016
    15. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    16. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    17. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    18. Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes Wound repair and regeneration · 2015
    19. In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing Cytotherapy · 2015
    20. Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells Experimental Dermatology · 2015
    21. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    22. Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014
    23. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    24. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    25. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    26. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    27. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    28. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    29. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    30. De Novo Formation and Ultra-Structural Characterization of a Fiber-Producing Human Hair Follicle Equivalent In Vitro Journal of biotechnology · 2011
    31. Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture Histochemistry and cell biology · 2010
    32. Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth Archives of dermatological research · 2008
    33. A Human Folliculoid Microsphere Assay for Exploring Epithelial-Mesenchymal Interactions in the Human Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    34. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    35. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006
    36. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    37. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    38. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003

    Related research 5

    1. Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice Journal of Investigative Dermatology · 2022
    2. Hair Follicle Bulge-Derived Stem Cells Promote Tissue Regeneration During Skin Expansion Biomedicine & Pharmacotherapy · 2020
    3. Promoting Effect of Hair Follicle Stem Cells in the Wound Healing of Skin Chin J Cell Stem Cell (Electronic Edition) · 2017
    4. Understanding the Functional Contribution of Dermal Stem Cells to Hair Follicle Regeneration and Skin Wound Healing 2017
    5. Interrogating the Integument: The Role of the Epidermis in Hair Induction Experimental dermatology · 2014