Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth

October 2008 in “ Archives of dermatological research ”

Naihui Zhou, Wenhong Fan, Meiyun Li

angiogenin dermal papilla cells hair growth RT-PCR western blotting immunofluorescence ELISA anagen phase skin angiogenesis anagen VI hair follicle elongation DPC proliferation vascularization DPCs PCR enzyme-linked immunosorbent assay blood vessel formation

Studysummary This study found that angiogenin is expressed in human dermal papilla cells, where it might stimulate hair growth by promoting cell proliferation and local skin angiogenesis.

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The study demonstrated that angiogenin, an angiogenic factor expressed in human dermal papilla cells (DPCs), significantly stimulated hair growth both in vivo and in vitro. Techniques such as RT-PCR, western blotting, immunofluorescence, and ELISA confirmed angiogenin's presence in DPCs, with peak expression during the late anagen phase. Local injections of angiogenin in mice promoted skin angiogenesis and induced anagen VI, while in vitro studies showed enhanced hair follicle elongation and DPC proliferation. These findings suggested that angiogenin could be a potential therapeutic target for promoting hair growth by stimulating cell proliferation and inducing local vascularization.

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