Mechanical Forces in Skin Disorders
March 2018
in “
Journal of Dermatological Science
”
mechanical forces skin disorders epidermolysis bullosa simplex extracellular matrix collagen keloids hypertrophic scars skin stiffness wound healing hair follicle development androgenetic alopecia scalp tension acral melanoma dermal stiffness squamous cell carcinoma recessive dystrophic epidermolysis bullosa mechanotransduction pathways skin blistering skin regeneration
TLDR Skin problems can be caused or worsened by physical forces and pressure on the skin.
The document reviewed the impact of mechanical forces on skin health and the development of various skin disorders. It explained that defects in skin cells and cell junction proteins can lead to conditions like epidermolysis bullosa simplex, which causes skin blistering. Changes in the extracellular matrix and collagen can result in keloids and hypertrophic scars due to excessive collagen production during healing. Skin stiffness was noted to affect wound healing and hair follicle development, with conditions like androgenetic alopecia being linked to scalp tension. The prevalence of acral melanoma in weight-bearing areas and the association of increased dermal stiffness with squamous cell carcinoma in recessive dystrophic epidermolysis bullosa patients were also discussed. The authors proposed that targeting mechanical forces or mechanotransduction pathways could offer new treatment avenues for skin diseases and aid in skin regeneration. However, the document is a review and does not provide specific study numbers or participant details.
