A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

April 2005 in “ The American journal of pathology (Print) ”

Enikő Bodó, Tamás Bı́ró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Paus

vanilloid receptor-1 TRPV1 capsaicin hair follicle hair shaft elongation cell proliferation apoptosis hair follicle regression transforming growth factor-ß₂ TGF-B₂ hair growth inhibitor

TLDR Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

The document from 2005 explores the role of the vanilloid receptor-1 (TRPV1) in human hair growth control. TRPV1, activated by capsaicin, was found to be expressed in human skin cells, including those in the hair follicle. The study showed that TRPV1 activation inhibits hair shaft elongation, suppresses cell proliferation, induces apoptosis, and leads to premature hair follicle regression. It also affects the expression of hair growth regulators, including up-regulating transforming growth factor-ß₂ (TGF-B₂), a known hair growth inhibitor. The findings suggest that TRPV1 could be a target for treating hair growth disorders and indicate its physiological importance extends to skin and hair follicle biology, beyond pain perception.

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A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

Research cited in this study

research Epithelial Growth Control by Neurotrophins: Leads and Lessons from the Hair Follicle

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

research Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice

research The Catalog of Human Hair Keratins

research Towards a Molecular Understanding of Hair Loss and Its Treatment

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin, and Hair Growth Modulation by Neuropeptides

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

research The Biology of Hair Follicles

research The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation

research The Catalog of Human Hair Keratins

research Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP

research Neural Mechanisms of Hair Growth Control

research Whole Hair Follicle Culture

research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

research Human hair growth in vitro

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