Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

February 2001 in “ Journal of Investigative Dermatology ”

Eva M.J. Peters, Vladimir A. Botchkarev, Natalia V. Botchkareva, Desmond J. Tobin, Ralf Paus

neuropeptides calcitonin-gene-related peptide substance P anagen progression neuropeptide receptor agonists neuropeptide receptor antagonists hair cycle regulation CGRP SP

Studysummary This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the role of sensory neuropeptides in hair follicle biology in C57BL/6 mice, focusing on the distribution and remodeling of sensory innervation during the hair cycle. It found that neuropeptides like calcitonin-gene-related peptide (CGRP) and substance P (SP) had distinct distribution patterns and significant changes during the hair cycle. SP accelerated anagen progression, while CGRP inhibited it, with CGRP's inhibitory effect counteracted by SP. The research suggested that these neuropeptides have different roles in hair growth control, indicating potential for using neuropeptide receptor agonists and antagonists in therapeutic hair growth manipulation. The study highlighted the complex interactions between neuropeptides and hair follicle innervation, suggesting their role in hair cycle regulation.

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research A Simple Immunofluorescence Technique for Simultaneous Visualization of Mast Cells and Nerve Fibers Reveals Selectivity and Hair Cycle-Dependent Changes in Mast Cell-Nerve Fiber Contacts in Murine Skin

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The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.

research Neural Mechanisms of Hair Growth Control

101 citations , January 1997 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.

research Hair Cycle-Dependent Changes in Skin Immune Functions: Anagen-Associated Depression of Sensitization for Contact Hypersensitivity in Mice

43 citations , April 1996 in “Journal of Investigative Dermatology”

research Peptidergic Innervation in the Sinus Hair Follicles of Several Mammalian Species

7 citations , October 1992 in “PubMed”

This study investigated peptidergic nerve fibers in sinus hair follicles of various mammals and found that CGRP fibers were more densely distributed than SP fibers across different regions of the follicles.

research Hair Growth In Vitro From Histocultured Skin

25 citations , August 1992 in “In vitro cellular & developmental biology”

The new system can grow hair in the lab and test hair growth treatments.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.