Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

The study investigated the role of sensory neuropeptides in hair follicle biology in C57BL/6 mice, focusing on the distribution and remodeling of sensory innervation during the hair cycle. It found that neuropeptides like calcitonin-gene-related peptide (CGRP) and substance P (SP) had distinct distribution patterns and significant changes during the hair cycle. SP accelerated anagen progression, while CGRP inhibited it, with CGRP's inhibitory effect counteracted by SP. The research suggested that these neuropeptides have different roles in hair growth control, indicating potential for using neuropeptide receptor agonists and antagonists in therapeutic hair growth manipulation. The study highlighted the complex interactions between neuropeptides and hair follicle innervation, suggesting their role in hair cycle regulation.