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    Glossary Squamous Cell Carcinoma

    type of skin cancer originating in outer epidermal cells

    Squamous Cell Carcinoma (SCC) is a type of skin cancer that originates in the squamous cells, which are flat cells located in the outer part of the epidermis. It often appears as a red, scaly patch, open sore, or wart-like growth that may crust or bleed. While it can be aggressive and spread to other parts of the body if not treated, it is generally curable when detected early.

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    1. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    2. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    3. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    4. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    5. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    6. Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors Cancer Research · 2008 · 64 citations
    7. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    8. The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells Pharmaceuticals · 2021 · 48 citations
    9. Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification The Journal of Dermatology · 2013 · 45 citations
    10. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
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