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    Glossary Squamous Cell Carcinoma

    type of skin cancer originating in outer epidermal cells

    Squamous Cell Carcinoma (SCC) is a type of skin cancer that originates in the squamous cells, which are flat cells located in the outer part of the epidermis. It often appears as a red, scaly patch, open sore, or wart-like growth that may crust or bleed. While it can be aggressive and spread to other parts of the body if not treated, it is generally curable when detected early.

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    1. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    2. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    3. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    4. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    5. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    6. Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors Cancer Research · 2008 · 64 citations
    7. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    8. The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells Pharmaceuticals · 2021 · 48 citations
    9. Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification The Journal of Dermatology · 2013 · 45 citations
    10. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    11. Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Cancer research · 2018 · 34 citations
    12. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    13. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    14. Aggressive squamous cell carcinoma developing in a giant epidermal cyst of the abdomen International Journal of Dermatology · 2006 · 16 citations
    15. Squamous cell carcinoma arising within folliculitis decalvans British Journal of Dermatology · 2008 · 15 citations
    16. No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma Journal of Investigative Dermatology · 2010 · 14 citations
    17. Connexin 26 (<i>GJB2</i>) mutations in keratitis–ichthyosis–deafness syndrome presenting with squamous cell carcinoma The Journal of Dermatology · 2011 · 11 citations
    18. Protein Kinase C<i>ε</i>, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells Journal of skin cancer · 2013 · 10 citations
    19. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    20. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    21. A Case of Squamous Cell Carcinoma of the Scalp After Several Synthetic Hair Grafts Aesthetic Plastic Surgery · 2012 · 5 citations
    22. Development of squamous cell carcinoma from erythroplasia of Queyrat following photodynamic therapy European Journal of Dermatology · 2018 · 3 citations
    23. Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions Small GTPases · 2011 · 3 citations
    24. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    25. Synthetic Hair Implantation and Squamous Cell Carcinoma of the Scalp Aesthetic Plastic Surgery · 2012 · 2 citations
    26. Horn With Miliary Calcification in Squamous Cell Carcinoma American Journal of Dermatopathology · 2003 · 2 citations
    27. Primary Cutaneous Rhabdoid Squamous Cell Carcinoma: A Case Report and Review of Molecular Features Cureus · 2024 · 1 citations
    28. GSDMA deficiency impairs cutaneous squamous cell carcinoma growth Frontiers in Oncology · 2026
    29. Squamous Cell Carcinoma of the Scalp Following Synthetic Hair Implantation: A Structured Narrative Review and the Seventh Case Reported in Literature Cureus · 2026
    30. Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful? Dermatology Practical & Conceptual · 2025