cAMP Response Element-Binding Protein 1 (CREB) Is a β-Catenin-Regulated Transcription Factor in Squamous Cell Carcinoma (SCC) Cells

    May 2018 in “ Journal of Investigative Dermatology ”
    K. Park, Y. Lee, Young-Joon Seo, J. Lee, Choonsig Kim
    Image of study
    TLDR CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.
    The document presents a study on the role of cAMP response element-binding protein 1 (CREB) in squamous cell carcinoma (SCC) cells, indicating that CREB is regulated by β-catenin and promotes cancer characteristics in SCC cells. The study involved overexpressing β-catenin in the human SCC13 cell line, which resulted in increased CREB expression. Further overexpression of CREB led to increased clonogenic activity, suggesting its role in enhancing cancer stemness. This provides new insights into the molecular mechanisms of cancer stemness regulation by β-catenin in SCC. The number of people or samples involved in the study is not mentioned in the abstract.
    Discuss this study in the Community →