CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

    September 2024 in “ Genes
    Zahid Hussain, Tingyan Hu, Yongchao Gou, Mingliang He, Xiaoyang Lv, Shanhe Wang, Wei Wang
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    TLDR CRABP1 boosts hair cell growth in Hu sheep by affecting key genes.
    This study investigates the role of CRABP1 in the proliferation of dermal papilla cells (DPCs) in Hu sheep, focusing on the Wnt/β-catenin signaling pathway. The research demonstrates that overexpression of CRABP1 enhances DPC growth and increases the proportion of S-phase cells, while CRABP1 knockdown results in reduced mRNA expression levels of CTNNB1, LEF1, and TCF4, which are crucial components of the Wnt/β-catenin pathway. These findings suggest that CRABP1 plays a significant role in regulating hair follicle development by influencing key genes in this signaling pathway, providing insights into the mechanisms of hair follicle morphogenesis.
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